Synthesis and Anti-hyperglycaemic Study of Aryl Sulfonate Ester Conjugated 5-arylidene-thiazolidine-2,4-diones

Abstract: Background: Diabetes mellitus, a lifestyle related global health crisis has rapidly engulfed the entire world. In past, various thiazolidinedione derivatives have been successfully developed for management of diabetes. Materials and Methods: Herein, we report synthesis, characterization (1H-NMR, 13C-NMR mass spectroscopy methods) novel aryl sulfonyloxy-5-arylidene thiazolidine-2,4-dione analogues. Anti-hyperglycaemic action (Alloxan-induced method) was performed evaluating antidiabetic potential synthesized compounds. Docking analysis final compounds were carried out to reveal interactions with active site pocket enzymes like protein tyrosine phosphatase 1B, aldose reductase peroxisome proliferator activated-γ. The further subjected ADME (Absorption, Distribution, Metabolism, Elimination) prediction studies prove their drug-like potential. Results: Compound 10 12 showed comparable reduction in blood sugar as that pioglitazone. helped understanding probable binding mode inside cavity concerned receptors. Conclusion: Aryl sulfonate esters phenyl chloro substituents found superior anti-hyperglycaemic activity. Key words: ADME, Anti-hyperglycaemic, sulfonyloxy-5-arylidenethiazolidine-2,4- dione, Docking, Spectral characterization.